Cytostatická léčiva v životním prostředí

Abstrakt

An increasing concern about contamination of the environment with pharmaceutical residues and their metabolites appeared recently. The contaminants get into hospital or municipal wastewater in considerable amounts, which may cause an adverse effect on the environment. Cytotoxic pharmaceuticals are considered to be genotoxic, mutagenic, carcinogenic, teratogenic and embryotoxic. Although the total amount of administered cytotoxic pharmaceuticals is much lower than that of analgesics or antibiotics, enhanced attention to this issue is reasonable due to their potential significant effect on the environment. The aim of this review is to resume the problems of occurrence, fate and ecotoxicological effects of  cytotoxic drugs in the environment including the efficiency of removing these compounds. Basic  characteristics of cytotoxic agents are included in the review.